Researchers at The University of Alabama (UA) and Oregon Health and Science University have identified Gardenin A, a flavonoid from a South Asian shrub, as a promising neuroprotective compound for Parkinson’s disease (PD). In mouse models, Gardenin A not only halted but also improved motor and cognitive symptoms.
Building on earlier findings in fruit flies, the UA team, led by Dr. Lukasz Ciesla and Dr. Urmila Maitra, confirmed its effects in genetic models, making it more relevant to human Parkinson’s cases. “This research is exciting because it suggests that Gardenin A can protect and improve both motor and cognitive symptoms in a genetic model of Parkinson’s disease, which is more similar to the human condition,” said Dr. Maitra.
The study also explored Gardenin A’s mechanism. Unlike its related molecule, Gardenin B, which only has antioxidant properties, Gardenin A exhibited neuroprotective effects, likely due to its anti-inflammatory action.
Looking ahead, Dr. Ciesla plans to study Gardenin A’s potential for Lewy body dementia and other neurodegenerative diseases, given its positive effects on memory symptoms. This research marks a promising step toward better Parkinson’s treatments.
“When people speak about Parkinson’s, they often focus on the motor dysfunction,” said Ciesla. “We found this molecule not only improves the mobility in mice, but it also seems to improve memory.”
Parkinson’s disease is a significant global health concern, with over 8.5 million individuals affected worldwide as of 2019. In the United States alone, nearly 90,000 people are diagnosed with PD each year, a 50% increase from previous estimates. These statistics underscore the urgent need for effective treatments.
The promising results from the Gardenin A study offer hope for new therapeutic avenues in combating this debilitating disease.
